Brazilian Journal of Microbiology Brazilian Journal of Microbiology
Braz J Microbiol 2018;49:347-50 - Vol. 49 Num.2 DOI: 10.1016/j.bjm.2017.06.008
Veterinary Microbiology
Efficacy of leptospiral commercial vaccines on the protection against an autochtonous strain recovered in Brazil
Rafael Bazaglia Sonadaa, Sérgio Santos de Azevedob, Francisco Rafael Martins Sotoc, Diego Figueiredo da Costab, Zenaide Maria de Moraisa, Gisele Oliveira de Souzaa, Amane Paldês Gonçalesd, Fabiana Miragliaa, Sílvio Arruda Vasconcellosa,,
a Universidade de São Paulo (USP), Faculdade de Medicina Veterinária e Zootecnia (FMVZ), São Paulo, SP, Brazil
b Universidade Federal de Campina Grande (UFCG), Centro de Saúde e Tecnologia Rural (CSTR), Patos, PB, Brazil
c Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP), Rão Roque, SP, Brazil
d Universidade de Santo Amaro (UNISA), São Paulo, SP, Brazil
Received 16 March 2017, Accepted 09 June 2017

In swine and bovines, leptospirosis prevention and control is carried out via vaccination of susceptible animals using bacterins. However, the efficiency of leptospirosis vaccines has been questioned. This work aimed to investigate the potency of five leptospirosis vaccines sold commercially in Brazil, challenging the animals with one autochthonous strain of Leptospira, Canicola serovar, denoted LO4, isolated from swine. The standard protocol was followed, and renal carriers of Leptospira were identified among the surviving animals by culture and PCR. Of the five vaccines tested, only two proved effective. None of the surviving animals was positive by culture; however, one animal was positive by PCR. Three of the five vaccines sold commercially in Brazil for the immunization of swine or bovines failed the test of the efficacy to protect the vaccinated animals following challenge with an autochthonous Leptospira strain, Canicola serovar. The two vaccines provided protection against the renal carrier state in the surviving animals. The criteria used to produce leptospirosis bacterins sold commercially in Brazil must be reviewed. The industry should support researches on leptospiral vaccinology to improve the quality of the present vaccines and discover new immunogenic strains, because it is known that vaccination is one of the most important tools to increase the reproduction rates in livestock.

Leptospirosis, Vaccination, Production animals, Control
Braz J Microbiol 2018;49:347-50 - Vol. 49 Num.2 DOI: 10.1016/j.bjm.2017.06.008