Brazilian Journal of Microbiology Brazilian Journal of Microbiology
Braz J Microbiol 2018;49:212-9 - Vol. 49 Num.2 DOI: 10.1016/j.bjm.2017.05.008
Review
Lactoferrin, chitosan and Melaleuca alternifolia—natural products that show promise in candidiasis treatment
Lorena de Oliveira Felipe, , Willer Ferreira da Silva Júnior, Katialaine Corrêa de Araújo, Daniela Leite Fabrino
Universidade Federal de São João del-Rei/Campus Alto Paraopeba, Minas Gerais, MG, Brazil
Received 18 August 2016, Accepted 26 May 2017
Abstract

The evolution of microorganisms resistant to many medicines has become a major challenge for the scientific community around the world. Motivated by the gravity of such a situation, the World Health Organization released a report in 2014 with the aim of providing updated information on this critical scenario. Among the most worrying microorganisms, species from the genus Candida have exhibited a high rate of resistance to antifungal drugs. Therefore, the objective of this review is to show that the use of natural products (extracts or isolated biomolecules), along with conventional antifungal therapy, can be a very promising strategy to overcome microbial multiresistance. Some promising alternatives are essential oils of Melaleuca alternifolia (mainly composed of terpinen-4-ol, a type of monoterpene), lactoferrin (a peptide isolated from milk) and chitosan (a copolymer from chitin). Such products have great potential to increase antifungal therapy efficacy, mitigate side effects and provide a wide range of action in antifungal therapy.

Keywords
Candida, Lactoferrin, Melaleuca alternifolia, Chitosan, Natural products
Braz J Microbiol 2018;49:212-9 - Vol. 49 Num.2 DOI: 10.1016/j.bjm.2017.05.008