Brazilian Journal of Microbiology Brazilian Journal of Microbiology
Braz J Microbiol 2016;47:785-92 - Vol. 47 Num.4 DOI: 10.1016/j.bjm.2016.06.005
Review
Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
Mariana Paganoa,c, Andreza Francisco Martinsb,c,, , Afonso Luis Bartha,c
a Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Farmácia, Programa de Pós-Gradução em Ciências Farmacêuticas, Porto Alegre, Brazil
b Universidade Federal do Rio Grande do Sul (UFRGS), Instituto de Ciências Básicas da Saúde, Porto Alegre, Brazil
c Hospital de Clínicas de Porto Alegre(HCPA), Porto Alegre, Brazil
Received 05 November 2014, Accepted 11 February 2016
Abstract

Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.

Keywords
Acinetobacter baumannii, Antimicrobial resistance, Mobile genetic elements, Carbapenem resistance
Braz J Microbiol 2016;47:785-92 - Vol. 47 Num.4 DOI: 10.1016/j.bjm.2016.06.005