Brazilian Journal of Microbiology Brazilian Journal of Microbiology
Braz J Microbiol 2018;49:785-9 - Vol. 49 Num.4 DOI: 10.1016/j.bjm.2017.12.010
Veterinary Microbiology
Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
Lúcio Ayres Caldasa,, , Tânia Rosária Pereira Freitasb, Renata Campos Azevedoc, Wanderley de Souzad
a Instituto Nacional de Metrologia, Qualidade e Tecnologia (INMETRO), Rio de Janeiro, RJ, Brazil
b Ministério da Agricultura, Pecuária e Abastecimento, Laboratório Nacional Agropecuário – LANAGRO – MG, Pedro Leopoldo, MG, Brazil
c Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Professor Paulo de Góes, Rio de Janeiro, RJ, Brazil
d Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, RJ, Brazil
Received 22 September 2017, Accepted 28 December 2017
Abstract

Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5μg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10μg/mL).

Keywords
Bovine viral diarrhea virus, BVDV, Prostaglandins, Prostaglandin A1, Virus-induced vacuolization
Braz J Microbiol 2018;49:785-9 - Vol. 49 Num.4 DOI: 10.1016/j.bjm.2017.12.010